There is a confirmed bug with OS X 10.10.3 where a kernel panic may occur when working with large JPEG files.

Kernel panics can be triggered when a large JPEG file is highlighted in the Finder when using anything but list view (icon view, column view, Cover Flow view), when QuickView is evoked on a large JPEG file using the Finder’s list view, or when a large JPEG file is opened in the Preview app.

OS X 10.10.3’s Preview app may also unexpected quit or become instable after opening a large JPEG file. This bug is affecting many different Mac models, and Apple is working on a fix.